ESTIMATION AND ASSESSMENT OF CYTOGENETIC CHANGES IN BONE MARROW CELLS OF LABORATORY ANIMALS RECEIVED A GENE-MODIFIED PRODUCT

  • N.A. Nuraliev Bukhara State medical institute named after Abu Ali ibn Sino, Bukhara, Uzbekistan
  • A.Kh. Allanazarov Urgench branch of the Tashkent Medical Academy, Tashkent, Uzbekistan
Keywords: genetically modified soybeans, cytogenetic changes, bone marrow, polyploidy, aneuploidy, experiment.

Abstract

Current trends in the change in the structure of morbidity indicate an increase in the relative importance of genetically determined diseases. The results of biological monitoring of human populations have shown that at present there is not only an increase in hereditary pathology, but also an increase in the frequency of diseases with a genetic component. The aim was to study cytogenetic changes in the cells of the bone marrow of laboratory animals that received and did not receive GMO soy. It is found in white mongrel rats treated with GMO soybean detected cytogenetic changes in their red om bone ohm brain e lead partially m the inhibition and proliferation of bone marrow cells. Of all be analyzed metaphases among them revealed altered karyotypes - polyploidy (5.6%) and aneuploidy (5.6%). In the remaining groups (group 2 and 3), no such changes were observed. In the group of animals that did not receive soy with and without GMO, all bone marrow samples had only metaphase plates with a normal karyotype, and the cells did not contain genomic abnormalities.

Published
2021-06-29