ACTIVITY OF CYTOTOXIC LYMPHOCYTES IN PATIENTS WITH PREECLAMPSIA

Abstract

With preeclampsia, the average levels of biochemical parameters in mild and severe form did not differ significantly from those in the group with uncomplicated preeclampsia of pregnancy. There is a tendency to a decrease in total protein and an increase in bilirubin, creatinine, urea, and blood trans- ferases as it becomes heavier. In the hemostatic system, there was also a tendency toward a decrease in fibrinogen and platelet count as gestosis worsened. The average hemostasis in the groups with pre- eclampsia did not differ from the group with uncomplicated pregnancy. However, thrombocytopenia was observed in 28% and 32% of cases with mild and severe forms of preeclampsia. Moreover, a pro- nounced decrease in platelet count (almost 10 times) was recorded in 5.4% of patients with severe pre- eclampsia. In patients with preeclampsia, the production of intracellular perforin in the regulatory cells- CD4+Perf+ lymphocytes was significantly reduced and increased - in natural killers CD16+Perf+ and CD56+Perf+.